. Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy. J Neurosci. 2003 Jan 15;23(2):493-502. PubMed.


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  1. This clearly demonstrates the involvement of amyloid in potent dystrophic neurite or curly fibre formation as seen in AD. Although it remains to clarify the chemical structure of amyloid b-protein, i.e., fiber, oligomeric or beta-structure, a link between amyloid and dystophic/synaptic failure is further evidenced (cf. Science (2002) 298: 789-91).