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Home: Papers of the Week
Annotation


Tong Y, Shen J. alpha-synuclein and LRRK2: partners in crime. Neuron. 2009 Dec 24;64(6):771-3. PubMed Abstract

  
Comments on Paper and Primary News
  Primary News: α-Synuclein Conspires With LRRK2 to Corrupt Neurons

Comment by:  Bharathi Shrikanth Gadad
Submitted 6 January 2010  |  Permalink Posted 13 January 2010

The paper aims to understand a novel physiological function of LRRK2 by mingling with the mutant α-synuclein protein. The approach seems fascinating. The authors plausibly suggest a link between LRRK2 and AD via the microtubule binding protein tau. However, several mechanisms run in parallel between AD and PD. The question arises whether it is a single disease with multiple kinds of dysfunction or multiple disorders?

View all comments by Bharathi Shrikanth Gadad
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PRIMARY NEWS
α-Synuclein Conspires With LRRK2 to Corrupt Neurons
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