Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M, Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME.
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.Nat Biotechnol.
Submit a Comment on this Paper
REAGENTS/MATERIAL: The cAMP concentration in the lysates was measured using a commercial enzyme-immunoassay (Biotrak, Amersham Biosciences) according to the manufacturer’s instructions. Quantification of LTE4 in plasma samples was determined using a commercial enzyme-linked immunosorbent assay (ELISA) from Cayman Chemicals following the manufacturers instructions.