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Annotation


Lopez-Alberola RF, Barker WW, Harwood DG, Loewenstein DA, George-Hyslop PH, Tsuda T, Rogaeva EA, Duara R. Interfamilial and intrafamilial phenotypic heterogeneity in familial Alzheimer's disease. J Geriatr Psychiatry Neurol. 1997 Jan;10(1):1-6. PubMed Abstract

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  Comment by:  Elliott Mufson, ARF Advisor (Disclosure)
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  Related Paper: Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations.

Comment by:  Hiroshi Mori, ARF Advisor
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  I recommend this paper

This is another peg to establish the role of presenilin molecules in AD, and tells us the significant function lies in the conserved sequence.

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