This is the first paper to show (11)C-PiB binding in PET in hereditary cerebral amyloid angiopathy and APP locus duplication. The paper reports increased uptake of (11)C-PiB in the striatum and the posterior cingulate in two cases with APP duplication, while there was only a marginal increase in cortical regions. The finding suggests that PIB-PET may be useful in investigating subjects with suspected CAA.

View all comments by Hilkka Soininen

A provocative paper providing new insights into the onset of Abeta amyloidosis in FAD. It also raises intriguing questions as to whether or not FAD and sporadic AD and Down syndrome evolve in the same locations and same manner. It also raises question about we are how to understand the disconnection between striatal Abeta deposits and the lack of clinical symptoms, signficant neuron loss, and tau pathology linked to striatal accumulations of Abeta deposits.

View all comments by John Trojanowski

These findings suggest more a loss of function of APP/AICD than a gain of toxic function, since there is no correlation between the precise early distribution of amyloid and clinical impairment.

View all comments by Andre Delacourte