|To Succeed, HRT Must Mimic Normal Hormone Physiology More Closely
Hormone replacement therapy (HRT) in humans has long been a rather crude enterprise, with, historically, the most common form of administration being a highly complex, partially purified fraction of the urine of pregnant horses. Typical treatment was continuous, rather than cyclical, and entirely estrogenic, with no accounting for the progestational arm of the cycle. Scientists studying the molecular basis of hormone action would not be surprised to learn that traditional continuous therapy with a poorly defined mixture of conjugated estrogens is not the optimal mimic of the human menstrual cycle.
Both estrogen and testosterone are reported to have a number of salutary neuroactive properties. Both are anti-amyloidogenic, as shown by Xu et al. in 1998, and, most recently, Rosario and Pike (2006). Segarra and McEwen demonstrated in 1991 that estrogen regulated dendritic spine density in rats. In this paper (Hao et al., 2007), Patrick Hof, John Morrison, and their colleagues demonstrated the importance...