Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Kallhoff V, Peethumnongsin E, Zheng H. Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2007;2:6. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Andrew Singleton, ARF Advisor
	Submitted 24 March 2007 \| Permalink	Posted 26 March 2007
	I recommend this paper

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REAGENTS/MATERIAL:
Antibodies used in this study are:
mouse monoclonal anti-Aβ (6E10) (Signet Covance); mouse monoclonal anti-α-synuclein (42) (BD Transduction); mouse monoclonal anti-MAP2 (HM-2) (Sigma Aldrich); rabbit anti-β-synuclein (Chemicon); rabbit anti-synaptophysin (Dako Cytomation)
Sandwich ELISAs for quantifying human AAβ40 and AAβ42 used 6E10 as the capture antibody and AB112 and AB115 as detection antibodies which recognize AAβ40 and AAβ42