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Home: Papers of the Week
Annotation


Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia. 1999 Feb 15;25(4):324-31. PubMed Abstract

Comments on Related Papers
  Related Paper: Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition.

Comment by:  Hiroshi Mori, ARF Advisor
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This provides histochemical evidence to support a role of the neprilysin in amyloidogenesis of AD brain. The immunoreactive intensity was not strong but favors its pathological involvement.

View all comments by Hiroshi Mori
  Related Paper: Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition.

Comment by:  Benjamin Wolozin, ARF Advisor (Disclosure)
Permalink
  I recommend this paper

"Neprilysin is a protease that degrades Ab and is emerging as an important regulator of Ab accumulation. The study of neprilysin represents a novel approach towards understanding Alzheimer’s pathophysiology, and understanding its biology represents a growth area for research in AD."

View all comments by Benjamin Wolozin
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Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition.
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