Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF. Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci. 2006 Dec 27;26(52):13428-36. PubMed Abstract, View on AlzSWAN

	Comments on Paper and Primary News

	Comment by: Takaomi Saido, ARF Advisor
	Submitted 7 January 2007 \| Permalink	Posted 7 January 2007
	I recommend this paper

	Comment by: Nikolaos K. Robakis
	Submitted 7 January 2007 \| Permalink	Posted 7 January 2007
	I recommend this paper

	Comment by: Tommaso Russo, ARF Advisor
	Submitted 8 January 2007 \| Permalink	Posted 8 January 2007
	I recommend this paper

	Comments on Related Papers

	Related Paper: Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Comment by: Andre Delacourte
	Submitted 6 May 2006 \| Permalink	Posted 7 May 2006
	I recommend this paper

	Related Paper: Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Comment by: Paul Coleman, ARF Advisor
	Submitted 5 May 2006 \| Permalink	Posted 7 May 2006
	I recommend this paper It is becoming increasingly evident that different flavors of APP/Aβ may modulate different functions. This paper contributes additional information to this topic. View all comments by Paul Coleman

	Related Paper: Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Comment by: H. Fai Poon
	Submitted 11 August 2007 \| Permalink	Posted 15 August 2007
	I recommend this paper This paper, again, indicates that Abeta is not the sole factor for AD development. It will be very exciting to see how all the contributing factors (e.g oxidative stress, protein synthesis/degradation, calcium etc) interact in the development of AD. View all comments by H. Fai Poon

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