HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, Liscic RM, Armendariz J, Morris JC, Goate AM. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Ann Neurol. 2006 Sep;60(3):314-22. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: John Trojanowski, ARF Advisor
	Submitted 23 September 2006 \| Permalink	Posted 27 September 2006
	I recommend this paper This study extends the findings on progranulin to include the HDD2 (hereditary dysphasic disinhibition dementia) family, thereby solving yet another important unsolved mystery about frontotemporal dementias. View all comments by John Trojanowski

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