This very interesting paper reports that treatment with an antibody against the EFRH sequence of β amyloid increases neurogenesis in the brains of mice carrying a mutant gene for amyloid precursor protein found in some patients with familial Alzheimer disease (AD).
This finding is of interest because it suggests that immunotherapy for AD might not only mobilize and remove amyloid from the brain, but also stimulate the production of new neurons, which could contribute to brain repair.
An important caveat in interpreting these findings is that, although newborn neurons in the brains of antibody-treated mice showed evidence of being functional cells, there is no evidence as yet that this improved behavioral or cognitive deficits in the mouse model.
Another interesting aspect of the study is that neurogenesis induced by EFRH immunization was found throughout the brain, and was not restricted to the classic neuroproliferative zones of the adult brain—dentate gyrus and subventricular zone. This means that either that newborn neurons arising in these regions migrated...