Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. J Biol Chem. 2006 May 26;281(21):14776-86. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Takaomi Saido, ARF Advisor
	Submitted 8 April 2006 \| Permalink	Posted 9 April 2006
	I recommend this paper

	Comment by: Bart De Strooper, ARF Advisor
	Submitted 8 April 2006 \| Permalink	Posted 9 April 2006
	I recommend this paper This paper sets the standard for gamma-secretase assays. The paper is also the last one in a nice series of publications of this group that convincingly demonstrates that gamma-secretase progressively cleaves APP protein starting from the epsilon cleavage down to the gamma-sites. View all comments by Bart De Strooper

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