Presenilin-1 mutations in Alzheimer's disease. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK. Presenilin-1 mutations in Alzheimer's disease. Nature. 2000 Jun 1;405(6786):531-2. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
	Permalink
	Mutations in PS1 have been shown to increase production of Ab42. This current publication suggests that mutations in PS1 might also affect cleavage at the N-terminus of Ab, leading to production of truncated Ab. View all comments by Benjamin Wolozin

	Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
	Permalink
	This is a striking finding indicating that mutations in PS1 affect more than the C-terminus of Ab. View all comments by Benjamin Wolozin

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