|A Way to Study the Function of Ionic Channels in AD Brains
In the last edition of PNAS, there is a very interesting paper in
which the authors show that it's feasible to analyze the function of neuronal
ionic channels in postmortem AD brains (1). The authors
have extracted membrane complexes from postmortem temporal cortex of
AD patients and controls, and injected it into Xenopus oocytes; the
brains used in the report were frozen for 1-9 years, with a
postmortem delay of 2-5 hours. Then, the authors recorded membrane
currents elicited after an application of GABA. They found differences in
the currents between patients and controls; no signal was seen in oocytes without injection. The study was under the direction
of Dr. Ricardo Miledi (University of California, Irvine), and it was
carried out as part of the postdoctoral work of Dr. Zulma Dueñas, a
Pew Latin American Fellow.
The article, featured on the cover of PNAS, opens new avenues for AD
research. The application of a new methodology for the functional
analysis of neural molecular...