Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, Doi H, Kurosawa M, Nekooki M, Nukina N. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med. 2004 Feb;10(2):148-54. PubMed Abstract

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REAGENTS/MATERIAL:

Heterozygous huntingtin exon-1–transgenic mice of strain R6/2 (bearing 145 CAG repeats) were obtained from The Jackson Laboratory.

Immunohistochemistry with antibody to ubiquitin (Dako) or NeuN (Chemicon) was performed on frozen sections of mouse brains. For Western blots primary antibodies to huntingtin (EM48) (Chemicon), expanded polyglutamine (1C2) (Chemicon) and b-tubulin (Sternberger Monoclonals) were used.