Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC.
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.Nat Neurosci.
PubMed Abstract, View on AlzSWAN
REAGENTS/MATERIAL: Antisera 4G8, which is specific to epitopes between residues 17-28 of Ab
Antisera CT15 (gift of Dr. Sisodia), which is specific for the carboxyl-terminal 15 residues of APP.
Homologous recombination in embryonic stem cells in generating BACE1-deficient mice.
FUTURE DIRECTION: BACE1 null mice are viable, it is possible to develop BACE1 inhibitors that ameliorate b-amyloid deposition without profound adverse effects.