Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science. 2001 Jul 20;293(5529):493-8. PubMed Abstract

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REAGENTS/MATERIAL:

Western blot and ELISA assays on cultured CNS cells as well as mouse brains were probed with rabbit polyclonal anti-brain-derived neurotrophic factor (BDNF) (sc546) 1:1000, (Santa Cruz).

Transgenic mouse model of HD overexpressing wild-type (YAC 18) or mutant full-length huntingtin (YAC 72) were used. The cerebral cortex, hippocampus and striatum were analysed for BDNF.

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