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Home: Papers of the Week
Annotation


Nitsch RM, Deng M, Tennis M, Schoenfeld D, Growdon JH. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol. 2000 Dec;48(6):913-8. PubMed Abstract

  
Comments on Paper and Primary News
  Comment by:  Eddie Koo, ARF Advisor
Permalink

First good evidence that the in vitro effects of muscarinic stimulation can be seen physiologically.

View all comments by Eddie Koo
  Comment by:  Rafael Rodríguez Puertas
Submitted 21 July 2003  |  Permalink Posted 22 July 2003
  I recommend this paper
  Comment by:  Abraham Fisher
Submitted 11 August 2003  |  Permalink Posted 12 August 2003
  I recommend this paper
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REAGENTS/MATERIAL:

Sandwich ELISA used to measure total amyloid-beta in CSF with monoclonal anti-Abeta (40) and anti-Abeta (42)(Signet).

Western blot analysis was done with anti-amyloid-beta (total) with 6E10.

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AF102B (Cevimeline or Evoxac) Lowers CSF Aβ in Alzheimer Patients
Desperately

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