Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K.
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.Proc Natl Acad Sci U S A.
1998 May 26;95(11):6460-4.
This is an interesting paper as it may explain the role of ApoE in Ab production as well as the mechanism of g-secretase cleavage. The problem is that no correlation has been demonstrated between cholesterol levels and AD.