Mayeux R, Saunders AM, Shea S, Mirra S, Evans D, Roses AD, Hyman BT, Crain B, Tang MX, Phelps CH.
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease.N Engl J Med.
1998 Feb 19;338(8):506-11.
This study using about 2,000 cases concludes that ApoE allele e4 is a risk factor and not a determinant factor of the disease. It, however, suggests a potent increase of the diagnosis if other factors are added for consideration.