This week, a study previously reported in our Conference News appeared in PNAS. In it, Thomas Willnow and colleagues describe how the trafficking protein sorLA, an LDL receptor, affects APP processing. Read Tom Fagan’s story from Sorrento, where Willnow presented this research.

Reference:
Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-13466. Epub 2005 Sep 7. Abstract

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References

News Citations

  1. Sorrento: Sorting Out Shedding of Ectodomains

Paper Citations

  1. . Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6. PubMed.

Further Reading

News

  1. Sorrento: Sorting Out Shedding of Ectodomains
  2. Paper Alert: SorLa and APP

Primary Papers

  1. . Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6. PubMed.