Just as amyloid-β toxicity may be attenuated by proteases such as insulin degrading enzyme and neprilysin, tau toxicity may be circumvented by the highly conserved puromycin-sensitive aminopeptidase (PSA)—at least in fruit flies. Alzforum first reported this possibility following George Jackson’s presentation at last year’s Society for Neuroscience annual meeting. Work from the lab of Jackson’s UCLA colleague Dan Geschwind had identified PSA as being enriched in the cerebellum of tau mutant (P301L) mice. Because the cerebellum escapes the ravages of tau toxicity, Jackson and colleagues tested if PSA could rescue tau toxicity in a fly model of neurodegeneration. They found that low-level overexpression of the peptidase reduced tau and prevented neurodegeneration of the fly eye.

The findings are presented in depth in today’s Neuron. First author Stanislav Karsten and colleagues also present data pointing to an increase in PSA in postmortem frontal cortex samples taken from patients with frontotemporal dementia. This “may reflect its higher level of expression in neurons surviving after a long course of disease,” the authors write. They also note that PSA colocalizes around senile plaques in AD brain (see Minnasch et al., 2003), suggesting a link between amyloid deposition and tau pathology that is worth further investigation. See our original SfN meeting coverage for more details on this study.—Tom Fagan

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Comments on News and Primary Papers

  1. The findings may possibly result in a breakthrough in the study of tauopathy, an essetial pathological propety of Alzheimer's disease.

    View all comments by Takaomi Saido

References

News Citations

  1. SfN: Return of the Other—Tau Is Back, Part 3

Paper Citations

  1. . Demonstration of puromycin-sensitive alanyl aminopeptidase in Alzheimer disease brain. Leg Med (Tokyo). 2003 Mar;5 Suppl 1:S285-7. PubMed.

Further Reading

Primary Papers

  1. . A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron. 2006 Sep 7;51(5):549-60. PubMed.