A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD. The findings from the University of Toronto and University of South Florida were reported earlier this year at scientific meetings (covered by this news forum). One of the Toronto coauthors, David Westaway, cautions: ``There is a complication still-the relationship between plaque and learning and memory might not be a straight-line one. But I think this does give us cause for optimism. We could have done this and come away with nothing.''-Hakon Heimer.

References:
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 2000 Dec 21-28;408(6815):979-82. Abstract

Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000 Dec 21-28;408(6815):982-5. Abstract

Chapman PF. Alzheimer's disease: model behaviour. Nature 2000 Dec 21-28;408(6815):915-6. Abstract

Comments

Make a Comment

To make a comment you must login or register.

Comments on this content

No Available Comments

Comments on Primary Papers for this Article

  1. Important animal model of AD.

    View all comments by Benjamin Wolozin
  2. Important animal model of AD.

    View all comments by Benjamin Wolozin
  3. Models of AD are clearly important.

    View all comments by Benjamin Wolozin

References

Paper Citations

  1. . A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):979-82. PubMed.
  2. . A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):982-5. PubMed.
  3. . Alzheimer's disease: model behaviour. Nature. 2000 Dec 21-28;408(6815):915-6. PubMed.

Further Reading

Papers

  1. . A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):979-82. PubMed.
  2. . A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):982-5. PubMed.
  3. . Alzheimer's disease: model behaviour. Nature. 2000 Dec 21-28;408(6815):915-6. PubMed.

Primary Papers

  1. . A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):979-82. PubMed.
  2. . A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):982-5. PubMed.
  3. . Alzheimer's disease: model behaviour. Nature. 2000 Dec 21-28;408(6815):915-6. PubMed.