When it comes to boosting cognition, any kind of activity may be better than nothing, according to results from the Mental Activity and eXercise Trial for Seniors (MAX). Led by Deborah Barnes, University of California, San Francisco, scientists compared a mix of vigorous mental and physical exercise with relaxed training to see if any intervention improved the cognitive performance of older adults more than the others. In the April 1 JAMA Internal Medicine online, the scientists report that the overall results of the trial were negative. Everyone improved equally, including the control group. Perhaps it’s not what you do; it’s how much you do it, said Barnes. “The type of activity may not be as important as just doing something, be it physical, mental, or social in nature,” she told Alzforum. Some experts questioned whether the trial was too short, or if the active controls too closely resembled the intervention groups.

Previous observational studies have suggested that both physical activity (see Larson et al., 2006, and Laurin et al., 2001) and mental stimulation (see ARF related news story) can curb the risk of developing dementia. Randomized controlled trials implied a causative effect, reporting that training the brain elevates test scores in the specific areas targeted by training (see ARF related news story), while exercising the body especially improves executive function (see Colcombe and Kramer, 2003). Would the two types of training together work even better? Few studies have investigated that question. In a small trial, researchers reported that two months of both aerobic and mental training improved memory in healthy elderly people more than either alone (see Fabre et al., 2002). On the other hand, a pilot trial found that four months of physical and mental training improved cognitive function no more than single interventions or an educational control (see Legault et al., 2011).

To explore the combined approach, Barnes and colleagues used a 2 x 2 factorial design to compare aerobic activity with stretching and toning and computerized cognitive training with educational videos. The study enrolled 126 older adults who lived on their own and complained of memory or thinking difficulties, but had neither dementia, exercised, or used computers intensively. For three months, half of the participants took three hour-long aerobics classes per week. Active controls spent those hours in stretching and muscle toning classes. Scientists further subdivided those two groups. Three days each week, half played an hour of computer games aimed at improving visual and auditory processing, while the rest watched educational DVDs and answered short questions.

At the beginning and end of the trial, the researchers evaluated verbal learning and memory, verbal fluency, processing speed, executive function, mental flexibility, and visuospatial function. They derived a single composite score for each person by averaging z scores from each test. Z scores are expressed in units of standard deviation (SD) and are comparable to effect size. All groups improved on average by 0.16 SD, but none more than any other. Effect sizes of 0.25-0.3 are considered clinically meaningful, said Barnes, and these data fall below that value. “It’s a small effect size, but these small improvements over the short term could have long-term implications,” said Barnes. “We just don’t know that yet.”

Why did all of the groups improve equally? Since all four exercised both brain and body in some fashion for six hours each week, perhaps time spent doing activities outweighs the importance of what one does exactly, Barnes told Alzforum. Alternatively, stretching and toning could match the potency of aerobic exercise, she said, effectively turning the active control group into an intervention group. Resistance training has improved cognition in previous studies (see Liu-Ambrose et al., 2010). Repeating the tests for cognitive function could also have contributed if the participants merely got better at test taking the second time around, the authors suggested. They added an intervention-free control group by giving cognitive tests to 12 more people and retesting them three months later. Their composite scores nudged up by 0.08 SD, implying that repeated testing explains some of the 0.16 SD uptick seen in the intervention groups.

Social interaction may have played a part, too, Barnes told Alzforum, as both exercise groups worked out in groups at a local YMCA. A previous study reported that socializing boosted brain volume and cognition in a group of elderly Chinese people (see Mortimer et al., 2012). It is also possible that the current study ended too quickly to detect differences, wrote the authors. This sentiment was echoed by Laura Baker, Wake Forest School of Medicine, Winston-Salem, North Carolina. Baker previously found that aerobic exercise enhanced executive function in women more than stretching by six months, but not yet at 12 weeks (see Baker et al., 2010). “Exercise slowly changes and restores health to many systems, so it may take some minimum amount of time for benefits to appear,” she said. A lack of full clinical evaluations and measurements of exercise intensity may have further limited the study, suggested the authors.

These results raise the question of how researchers should design controls. “Often, in the attempt to match intervention and control groups in all aspects except the intervention, there is a risk that not enough contrast exists,” wrote Nicola Lautenschlager, University of Melbourne, Australia, and Kay Cox, University of Western Australia, in an accompanying editorial. Future trials with active controls should run longer to see if a difference arises, Lautenschlager told Alzforum. Similar studies should also include biomarker measurements to root out the underlying biological mechanisms that improve cognition and function, wrote Cox and Lautenschlager.

Upcoming studies are poised to further explore the advantages of aerobic exercise or its combined effects with mental stimulation. An 18-month Alzheimer’s Disease Cooperative Study trial led by Baker and Carl Cotman of the University of California at Irvine will compare stretching to aerobic exercise in 300 sedentary adults with MCI (see ARF related news story). Though these scientists do not plan to include an additional intervention-free control, as Barnes suggests, this paper could cause them to reexamine that decision, said Baker. Additionally, the ongoing 18-month Study of Mental Activity and Regular Training (SMART) trial (see Gates et al., 2011) headed by Maria Singh at the University of Sydney, Lidcombe, Australia, will compare whole-body resistance exercise and computerized cognitive training with seated calisthenics and educational video watching to see if either or both of the more intense interventions more strongly affect global cognitive function and brain morphology in old adults. Several ongoing lifestyle modification trials in Europe also incorporate physical and mental stimulation (see ARF related news story). These trials will be large enough to examine whether multipronged approaches can reduce the incidence of dementia, said Lautenschlager.—Gwyneth Dickey Zakaib

Comments

Make a Comment

To make a comment you must login or register.

Comments on this content

No Available Comments

References

News Citations

  1. Add Mental Exercise to Potential AD Protection
  2. The ACTIVE Trial—Long-Term Effects of Cognitive Training
  3. Europe Asks If Reforming Health Habits Can Prevent Dementia

Paper Citations

  1. . Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med. 2006 Jan 17;144(2):73-81. PubMed.
  2. . Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001 Mar;58(3):498-504. PubMed.
  3. . Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003 Mar;14(2):125-30. PubMed.
  4. . Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects. Int J Sports Med. 2002 Aug;23(6):415-21. PubMed.
  5. . Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trial. BMC Geriatr. 2011;11:27. PubMed.
  6. . Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med. 2010 Jan 25;170(2):170-8. PubMed.
  7. . Changes in brain volume and cognition in a randomized trial of exercise and social interaction in a community-based sample of non-demented Chinese elders. J Alzheimers Dis. 2012;30(4):757-66. PubMed.
  8. . Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol. 2010 Jan;67(1):71-9. PubMed.
  9. . Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial. BMC Geriatr. 2011;11:19. PubMed.

Other Citations

  1. ARF related news story

External Citations

  1. Mental Activity and eXercise Trial for Seniors
  2. Alzheimer’s Disease Cooperative Study
  3. Study of Mental Activity and Regular Training

Further Reading

Papers

  1. . Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review. Ageing Res Rev. 2013 Jan;12(1):263-75. PubMed.
  2. . Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2008;(3):CD005381. PubMed.
  3. . Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003 Mar;14(2):125-30. PubMed.
  4. . Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Sci. 2003 Feb;58(2):176-80. PubMed.
  5. . Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 2005 Nov;4(11):705-11. PubMed.
  6. . Cognitive activity and incident AD in a population-based sample of older persons. Neurology. 2002 Dec 24;59(12):1910-4. PubMed.
  7. . Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA. 2002 Nov 13;288(18):2271-81. PubMed.
  8. . Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):205-10. PubMed.
  9. . Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008 Sep 3;300(9):1027-37. PubMed.
  10. . Ageing, fitness and neurocognitive function. Nature. 1999 Jul 29;400(6743):418-9. PubMed.

Primary Papers

  1. . The Mental Activity and eXercise (MAX) Trial: A Randomized Controlled Trial to Enhance Cognitive Function in Older Adults. JAMA Intern Med. 2013 Apr 1;:1-8. PubMed.
  2. . Can Participation in Mental and Physical Activity Protect Cognition in Old Age?Comment on "The Mental Activity and eXercise (MAX) Trial: A Randomized Controlled Trial to Enhance Cognitive Function in Older Adults". JAMA Intern Med. 2013 Apr 1;:1-2. PubMed.