Missed last Tuesday’s Science Times? Go fish it out of the recycling bin. The New York Times ran an extensive piece by writer Gina Kolata on recent advances. Alzforum has been covering all this research closely over the years, but our readers might get a kick out of seeing how a national newspaper threads it together into a story about new hope for therapeutic strategies invigorating the field.

Top of Kolata’s list is the finding that in people with late-onset AD, clearance of amyloid-β (Aβ) from the brain is more of a problem than overproduction. Alzforum reported this when Randall Bateman, Washington University, St. Louis, Missouri, presented it at the International Conference on Alzheimer’s Disease in Honolulu last July (see ARF related news story). Formally published in the December 9 Sciencexpress (see ARF related news story), the study found that Aβ exits the CSF more slowly as people age, and most slowly in those with AD. This is the latest study in bold research on human volunteers Bateman first published in 2006 (see ARF related news story).

Kolata also highlights work from David Holtzman’s lab, also at WashU, and Roberto Malinow’s lab at University of California, San Diego, revealing roles for Aβ in normal (see ARF related news story) and dysfunctional synaptic activity (see ARF related news story), and tying Aβ to synaptic activity in humans for the first time (see ARF related news story).

The place of tau in pathology, as described in recent studies from Lennart Mucke’s lab at University of California, San Francisco (see ARF related news story and ARF news story), also makes the list, as does the default-mode network, a matrix of interconnected brain regions that are particularly prone to accumulate amyloid plaques and succumb to neurodegeneration in AD (see, e.g., ARF related news story, ARF news story, and ARF news story). Taken together, these advances point to new ways to understand and attack the disease, writes Kolata. Recycling gone? Read the New York Times piece here. And while you are already taking in Alzheimer's coverage in one major newspaper, read also Sandra Day O'Connor and Maria Shriver's call in the Washington Post for visionary leadership so this nation can rally the will and resources to averting a national epidemic of this disease.—Tom Fagan and Gabrielle Strobel.

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References

News Citations

  1. Honolulu: Wake-Up Call—Aβ Clearance, Not Production, Awry in AD
  2. Paper Alert: In Vivo Human Data Shows Reduced Aβ Clearance in AD
  3. CSF Aβ—New Approach Shows Rapid Flux, May Help Evaluate Therapeutics
  4. Link Between Synaptic Activity, Aβ Processing Revealed
  5. Aβ—Made Globally, Acts Locally
  6. Soluble Aβ—Bane or Boon? Real-time Data in Humans Yield New Insight
  7. The Plot Thickens: The Complicated Relationship of Tau and Aβ
  8. APP Mice: Losing Tau Solves Their Memory Problems
  9. Network Diagnostics: "Default-Mode" Brain Areas Identify Early AD
  10. Tracing Alzheimer Disease Back to Source
  11. Brain Aβ Patterns Linked to Brain Energy Metabolism

External Citations

  1. New York Times piece here
  2. Washington Post

Further Reading