The mechanisms of regulated α-secretase cleavage were thoroughly examined in two excellent companion posters from Virginia Lee’s lab (240.2, 240.3). The authors demonstrated that TNFalpha converting enzyme (TACE) knockout mice show reduced sensitivity to PMA and consequently secrete less α-cut APPalpha in response to treatment with phorbol esters. Although Moore was careful to point out that non-TACE activities were capable of α-secretase-like cleavage, transfection of TACE KO mice increased both constitutive and regulated APPa secretion.-Dominic Walsh.
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