Several groups have reported a lack of phenotype in α-synuclein (α-S) transgenic mice, but it appears Lennart Mucke (122.10) has got it right. Mucke reported that inclusion bodies were obvious in PDGF promoter-driven α-S Tg mice as early as three-four months, and that these inclusions were most obvious in the higher expressing lines. Moreover, bigenic APP/α-S mice showed an increase in the number of Lewy body-like inclusions and displayed memory and learning deficits greater than mice carrying a single transgene. These observations suggest that interactions between Aα and α-S contribute significantly to dementia with Lewy bodies.-Dominic Walsh.

Comments

Make a Comment

To make a comment you must login or register.

Comments on this content

No Available Comments

Comments on Primary Papers for this Article

No Available Comments on Primary Papers for this Article

References

No Available References

Further Reading

No Available Further Reading