|
20 December 2000. A trio of articles will appear in tomorrow's issue of Nature,
reporting that Aβ peptide immunization reduces a memory deficit in transgenic
mouse models of AD. The findings from the University of Toronto and University
of South Florida were reported earlier this year at scientific meetings (covered
by this news forum). One of the Toronto coauthors, David Westaway, cautions:
``There is a complication still-the relationship between plaque and learning
and memory might not be a straight-line one. But I think this does give us cause
for optimism. We could have done this and come away with nothing.''-Hakon Heimer.
References:
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 2000 Dec 21-28;408(6815):979-82. Abstract
Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000 Dec 21-28;408(6815):982-5. Abstract
Chapman PF. Alzheimer's disease: model behaviour. Nature 2000 Dec 21-28;408(6815):915-6. Abstract
|
Home
View all comments by Benjamin Wolozin
