|
|
|
| First Name: | Norman | | Last Name: | Haughey | | Title: | Assistant Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | Johns Hopkins School of Medicine | | Department: | Neurology | | Street Address 1: | Meyer 6-109. 600 North Wolfe Street | | City: | Baltimore | | State/Province: | MD | | Zip/Postal Code: | 21287 | Country/Territory: | U.S.A. | | Phone: | 443-287-3825 | | Fax: | 410-955-0672 | | Email Address: |  |
Disclosure:
(view policy)
|
Member reports no financial or other potential conflicts of interest. [Last Modified: 21 June 2004]
|
|
|
View all comments by Norman Haughey
|
Microscopy, Animal Models, Protein structure/chemistry, Apoptosis/Cell cycle, Neurobiology, Oxidative Stress, Neuroimmunology, Chemistry/Pharmacology, Proteomics, Signal transduction, Stem cells, A-beta PP/A-beta, DNA microarrays, Electrophysiology
|
Dr. Norman Haughey's research focuses on signaling pathways that promote the dysfunction and death of neuronal cells. In this context, he is interested in the mechanisms that promote neurotoxic processes in HIV and Alzheimer's related dementias. Dr. Haughey and his colleagues use a multidisciplinary approach including tissue culture, molecular reconfiguration, transgenic or knock-out mice and biochemical approaches in order to identify and modify signal transduction pathways that are associated with neurodegenerative processes. Using these model systems, they have described pathogenic modifications of calcium permeable receptors and transporters that promote excessive calcium accumulation. Current research is focused on mapping perturbations in lipid raft based signal transduction pathways that lead to the oxidative modification of subcellular targets involved apoptotic and anti-apoptotic signaling.
A second research interest is in the biology of neural stem and neural progenitor cells. In particular, he is interested in the mechanisms that govern the function and survival of neural stem and neural progenitor cells and how these processes are disrupted in neurodegenerative conditions.
|
Haughey, N.J., Liu, D., Nath, A., Borchard, A.C., and Mattson, M.P. (2002). Disruption of Cortical Neurogenesis by Amyloid b-Peptide: Implications for the Pathogenesis of Alzheimer’s Disease. Neuro. Mol. Med. 1: 125-135.
Tomac, A.C., Agulnick, A., Haughey, N., Chang, C., Bäckman, C., Zhang, Y., Morales, M., Matsson, M.P., Wang, Y., Westphal, H., Hoffer. B.J. (2002). Persephin is a Pivotal Modulator in Cerebral Ischemia: EvidenceFrom Null Mutations and Pharmacological Studies. PNAS. 99(14):9521-9526.
Chan, S.L., Culmsee, C., Haughey, N.J., Kapper, W., Mattson, M.P. (2002). Presenilin-1 Mutation Sensitizes Neurons to DNA Damage-induced Apoptosis by a Mechanism involving Perturbed Calcium Homeostasis and Activation of Calpain and Caspase 12. Neurobiology of Disease. 11(1):2-19
Haughey N.J., Mattson M.P., (2002). Calcium Dysregulation and Neuronal Apoptosis by the HIV-1 Proteins Tat and gp120. J Acquir Immune Defic Syndr. 2002 Oct 1;31 Suppl 2:S55-61.
Mattson MP, Duan W, Chan SL, Cheng A, Haughey N, Gary DS, Guo Z, Lee J, Furukawa K. (2002). Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior. Neurobiol Aging. Sep;23(5):695.
Haughey N., Conant, K., Nath A., Hillaire C.S., Gary D.S., Pardo C.A., Wahl L.M., Bilak M., Milward E., Mattson M.P. (2002). Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9. J Neurochem. 82(4):885-893
Haughey, N.J., Nath, A., Liu, D., Chan, S.L., Borchard, A. , and Mattson, M.P. (2002). Disruption of Neurogenesis by Amyloid b-Peptide in Experimental Models of Alzheimer’s Disease. J. Neurochem. 83(6):1509-1524.
Haughey, N.J., Mattson, M.P. (2003). Alzheimer’s Amyloid _-Peptide Enhances ATP/Gap Junction-Mediated Calcium Wave Propagation in Astrocytes. Neuromolecular Med. 3(3):173-180.
McCullough, L., Liejun, W., Haughey, N., Liang, X., Hand, T., Wang, Q., Breyer, R., Andreasson, K. (2003). Neuroprotective Function of the PGE2, EP2 Receptor in Cerebral Ischemia. Journal of Neuroscience. 7;24(1): 257-268.
Haughey, N.J., Cutler, R.G., Tamara, A, McArthur, J.C., Vargas, D.L., Pardo, C.A., Turchan, J., Nath, A., Mattson, M.P. (2004). Involvement of Perturbed Sphingolipid Metabolism and Ceramide Production in the Pathogenesis of HIV Dementia. Annals of Neurology. 55, 257-267.
|
trigger for abberant amyloid processing in late-onset Alzheimer's disease |
|
|
Home
