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| First Name: | Magnus | | Last Name: | Azuine | | Title: | Dr. | | Advanced Degrees: | Ph.D. | | Affiliation: | George Washington University & Veterans Affairs Medical Center | | Department: | Lipid Research Laboratory 151-T | | Street Address 1: | 50 Irving Street, NW | | City: | Washinngton | | State/Province: | DC | | Zip/Postal Code: | 20422 | Country/Territory: | U.S.A. | | Phone: | 202-745-8000 | | Fax: | 202-462-2006 | | Email Address: |  |
Disclosure:
(view policy)
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Aging Process, Neurodevelopmental Disorders (Down syndrome, etc.), Alzheimer Disease
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Molecular and Cell biology, Chemistry/Pharmacology, Protein structure/chemistry, Tau/Cytoskeleton, Animal Models, Neurobiology, Oxidative Stress, DNA microarrays
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Medical hospital, University
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Dr. Azuine is currently a Research Scientist at both The Veterans Affairs Medical Center, Washington DC and the Departments of Medicine, Biochemistry and Molecular Biology, The George Washington University, Washington DC. He is also a Visiting Scientist, Department of Pharmaceutical Sciences, Howard University, Washington, DC. Dr. Azuine is also the President of TransWorld Development Intiatives Inc., a worldwide independent charity organization. He holds a Ph.D. (Biochemistry) from the University of Bombay, India after working at the Cancer Research Institute, Tata Memorial Center, Bombay. He completed a postdoctoral training at the Institute for Pharmacy, Free University, Berlin, Germany. He served extensively as a Research Scientist, first at the National Institute for Medical Research, Lagos, Nigeria and later the National Institute for Pharmaceutical Research and Development, Abuja, Nigeria. He also worked as Adjunct Professor of Biology, Bowie State University, and Instructor, the Department of Applied and Basic Sciences, and the Discover Sciences Program, Montgomery College, both in Maryland, USA. He has published extensively in international scientific journals and made contributions to many books. In Biomedical Sciences, he has introduced new concepts including “Adjuvant Chemoprevention of Cancer” in J. Ethnopharmacology 44: 211 (1994) and “Hypothesis – Transplacental Chemoprevention of Cancer in J. Transfigural Mathematics 4: 59 (1998). He is a recipient of the Alexander von Humboldt Research Fellowship Award (Germany), and the American Institute for Cancer Research (USA). He is the author of the book “Cancer and Ethnobotany of Nigeria” (1998) Shaker Verlag, Germany (www.shaker.de). Dr. Azuine has been involved in community and philanthropic organization since the ‘80s, and while doing a National Youth Service started the Cancer Enlightenment Society of Nigeria (1992). He is a member of the Nigerian Red Cross Society and wrote extensively as a Health Columnist in Abuja Mirror, a weekly newspaper where he teaches the fundamentals of various health issues to the general public. |
1: Azuine MA, Patel SJ, Lakshman MR.
Effects of chronic ethanol administration on the activities and relative synthetic rates of myelin and synaptosomal plasma membrane-associated sialidase in the rat brain.
Neurochem Int. 2005 Oct 6; [Epub ahead of print]
PMID: 16214265 [PubMed - as supplied by publisher]
2: Azuine MA, Patel SJ, Lakshman MR.
Chronic ethanol feeding controls the activities of various sialidases by regulating their relative synthetic rates in the rat liver.
Metabolism. 2005 Aug;54(8):1056-64.
PMID: 16092056 [PubMed - indexed for MEDLINE]
3: Azuine MA, Tokuda H, Takayasu J, Enjyo F, Mukainaka T, Konoshima T, Nishino H, Kapadia GJ.
Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models.
Pharmacol Res. 2004 Feb;49(2):161-9.
PMID: 14643696 [PubMed - indexed for MEDLINE]
4: Kapadia GJ, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H. Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Pharmacol Res. 2003 Feb;47(2):141-8.
PMID: 12543062 [PubMed - indexed for MEDLINE]
5: Kapadia GJ, Azuine MA, Tokuda H, Takasaki M, Mukainaka T, Konoshima T, Nishino H. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Pharmacol Res. 2002 Jun;45(6):499-505.
PMID: 12162952 [PubMed - indexed for MEDLINE]
6: Kapadia GJ, Azuine MA, Tokuda H, Hang E, Mukainaka T, Nishino H, Sridhar R.
Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation.
Pharmacol Res. 2002 Mar;45(3):213-20.
PMID: 11884218 [PubMed - indexed for MEDLINE]
7: Kapadia GJ, Azuine MA, Balasubramanian V, Sridhar R.
Aminonaphthoquinones--a novel class of compounds with potent antimalarial activity against Plasmodium falciparum.
Pharmacol Res. 2001 Apr;43(4):363-7.
PMID: 11352541 [PubMed - indexed for MEDLINE]
8: Kapadia GJ, Azuine MA, Takayasu J, Konoshima T, Takasaki M, Nishino H, Tokuda H.
Inhibition of epstein-barr virus early antigen activation promoted by 12-O-tetradecanoylphorbol-13-acetate by the non-steroidal anti-inflammatory drugs.
Cancer Lett. 2000 Dec 20;161(2):221-9.
PMID: 11090973 [PubMed - indexed for MEDLINE]
9: Azuine MA, Bhide SV.
Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models.
J Ethnopharmacol. 1994 Dec;44(3):211-7.
PMID: 7898128 [PubMed - indexed for MEDLINE]
10: Bhide SV, Azuine MA, Lahiri M, Telang NT.
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products.
Breast Cancer Res Treat. 1994;30(3):233-42.
PMID: 7526904 [PubMed - indexed for MEDLINE] |
Is there a relationship between alcohol and alzheimer's disease? |
1: Chin J, Palop JJ, Puolivali J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L.
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
J Neurosci. 2005 Oct 19;25(42):9694-703.
PMID: 16237174 [PubMed - in process]
2: Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L.
Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.
J Neurosci. 2005 Oct 19;25(42):9686-93.
PMID: 16237173 [PubMed - in process]
3: Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L.
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
Nat Med. 2004 Nov;10(11):1190-2. Epub 2004 Oct 24.
PMID: 15502844 [PubMed - indexed for MEDLINE]
4: Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L.
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.
J Neurosci. 2004 May 12;24(19):4692-7.
PMID: 15140940 [PubMed - indexed for MEDLINE]
5: Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L.
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9572-7. Epub 2003 Jul 24.
PMID: 12881482 [PubMed - indexed for MEDLINE]
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Is there a relationship between alcohol and alzheimer's disease? |
Since alcohol modulates the ganglioside microheterogenicity in the brain, there is certainly a relationship between alcohol and alzheimer's disease. |
Alcohol will either up-regulate or down-regulate the progress to alzheimer's disease. |
I am interested in collaboration and sharing of research experience. |
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