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Home: Community: Researcher Profiles
Researcher Profile

RESEARCHER INFORMATION
First Name:Yuzhi
Last Name:Chen
Title:Assistant Professor
Advanced Degrees:Ph.D.
Affiliation:The University of Arkansas for Medical Sciences
Department:Geriatrics
Street Address 1:629 Jack Stephens Drive
Street Address 2:COA Rm 3166, Slot 807
City:Little Rock
State/Province:AR
Zip/Postal Code:72205-7199
Country/Territory:U.S.A.
Phone:501-526-5805
Fax:501-526-5830
Email Address: 
Disclosure:
(view policy)  		Member reports no financial or other potential conflicts of interest. [Last Modified: 15 January 2004]
View all comments by Yuzhi Chen
Clinical Interests:
Alzheimer Disease, Aging Process, Neurodevelopmental Disorders (Down syndrome, etc.)
Research Focus:
Apoptosis/Cell cycle, Stem cells, A-beta PP/A-beta, Signal transduction, Tau/Cytoskeleton, Molecular and Cell biology
Work Sector(s):
University
Web Sites:
Professional: http://www.uams.edu
Lab: http://www.centeronaging.com/faculty/detail.asp?offset=10&ID=94
Top Papers
1. Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J Cell Biol. 2003 Oct 13; 163(1): 27-33. PMID: 14557245

2. Chen Y, Liu W, Naumovski L, Neve RL. ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.
J Neurochem. 2003 May; 85(3): 801-9.
PMID: 12694406

3. Chen Y, McPhie DL, Hirschberg J, Neve RL.
The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons.
J Biol Chem. 2000 Mar 24; 275(12): 8929-35.
PMID: 10722740

4. Chen Y, Norkin LC. Related Articles, Links
Extracellular simian virus 40 transmits a signal that promotes virus enclosure within caveolae.
Exp Cell Res. 1999 Jan 10; 246(1): 83-90.
PMID: 9882517

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