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| First Name: | Andrea | | Last Name: | Tenner | | Title: | Professor | | Advanced Degrees: | PhD | | Affiliation: | University of California, Irvine | | Department: | Molecular Biology and Biochemistry | | Street Address 1: | 3205 McGaugh Hall | | City: | Irvine | | State/Province: | CA | | Zip/Postal Code: | 92697-3900 | Country/Territory: | U.S.A. | | Fax: | 949-824-8551 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 6 July 2008]
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View all comments by Andrea Tenner
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Aging Process, Stroke and Trauma, Alzheimer Disease
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Animal Models, A-beta PP/A-beta, Molecular and Cell biology, Neuroimmunology, Neuropathology, Signal transduction
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ANDREA J. TENNER, PH.D.
Education: Ph.D., University of California, San Diego, 1977; B.A., University of Dallas, Irving, Texas, 1972.
Professional Experience: Professor, Departments of Molecular Biology and Biochemistry, Pathology, and Neurobiology and Behavior, University of California, Irvine 1992-present; Associate Dean for Research, UCI School of Biological Sciences 2007-present; Associate Director, UCI Center for Immunology, 2003-2007; Executive Committee, UCI Alzheimer’s Disease Research Center, 1999-present. Scientist II, 1986-1991, Biochemistry Laboratory, American Red Cross Holland Laboratories, Rockville, MD; Senior Staff Fellow, NIH, 1983-1986; Assistant Member, Scripps Institute and Research Foundation, 1981-83; Postdoctoral Fellow, Scripps Institute and Research Foundation, 1977-81.
Honors and Professional Activities: Fellow, American Association for the Advancement of Science, 1994; International Complement Workshop Organizing Committee, 1996 2000; Councilor, International Complement Society, 2000-present; Councilor, Society of Leukocyte Biology, 2005-present; Member, Committee on Status of Women, AAI, 2005-present. UCI Emeritae/i Association Faculty Mentorship Award, 2005-06.
Journal of Neuroinflammation, Editorial Board, 2004-present; Autoimmunity, Advisory Board, 2003-2005; Journal of Immunology, Associate Editor, 1993-1998; UC AIDS Research Program Task Force, 2000-2004; American Heart Association, California Affiliate, Peer Review, South Committee, 1993-1997; Howard Hughes Medical Institute, Predoctoral Fellowships in Biological Sciences, 2000, 2001; Equity Advisory to the Dean, UCI School of Biological Sciences, 2004-2007; NIH III Study Section, 2005-present.
Research Interests: Innate Immunity, Complement, Inflammation, Phagocytosis, Alzheimer’s Disease, Neurodegeneration
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Pisalyaput K. and Tenner A. J. (2008) Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms. J Neurochem. 104, 696-707.
Webster S. D., Galvan M. D., Ferran E., Garzon-Rodriguez W., Glabe C. G. and Tenner A. J. (2001) Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J. Immunol. 166, 7496-7503.
Tenner A. J. and Fonseca M. I. (2006) The double-edged flower: roles of complement protein C1q in neurodegenerative diseases. Adv. Exp Med Biol 586, 153-176.
Zhou J., Fonseca M. I., Kayed R., Hernandez I., Webster S. D., Yazan O., Cribbs D. H., Glabe C. G. and Tenner A. J. (2005) Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. J Neuroinflammation. 2, 28.
Webster S. D., Yang A. J., Margol L., Garzon-Rodriguez W., Glabe C. G. and Tenner A. J. (2000) Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp. Neurol. 161, 127-138.
Fan R. and Tenner A. J. (2005) Differential regulation of Abeta42-induced neuronal C1q synthesis and microglial activation. J Neuroinflammation. 2, 1.
Li M., Pisalyaput K., Galvan M. and Tenner A. J. (2004) Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microglia-mediated neurotoxicity. J Neurochem. 91, 623-633.
Fonseca M. I., Zhou J., Botto M. and Tenner A. J. (2004) Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci. 24, 6457-6465.
Afagh A., Cummings B. J., Cribbs D. H., Cotman C. W. and Tenner A. J. (1996) Localization and cell association of C1q in Alzheimer's disease brain. Exp. Neurol. 138, 22-32.
Jiang H., Burdick D., Glabe C. G., Cotman C. W. and Tenner A. J. (1994) -amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J. Immunol. 152, 5050-5059.
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