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| First Name: | Michael | | Last Name: | Zagorski | | Title: | Associate Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | Case Western Reserve University | | Department: | Chemistry | | Street Address 1: | 2074 Adelbert Road | | City: | Cleveland | | State/Province: | OH | | Zip/Postal Code: | 44106-7078 | Country/Territory: | U.S.A. | | Phone: | 216-368-3706 | | Fax: | 216-368-3006 | | Email Address: |  |
Disclosure:
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View all comments by Michael Zagorski
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Aging Process, Alzheimer Disease, Polyglutamine Disorders (Huntington's, etc.), Prion Diseases, Parkinson Disease
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Protein structure/chemistry, A-beta PP/A-beta, Chemistry/Pharmacology, Bioinformatics/Statistics, Oxidative Stress
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Michael G. Zagorski
Associate Professor of Chemistry
Physical Organic Chemistry and Molecular Biophysics
B.S., SUNY at Oneonta, 1978
Ph.D., Case Western Reserve University, 1983
NIH Postdoctoral Fellow, Columbia University, 1983-86
Research Scientist, College of Physicians & Surgeons, Columbia University, 1986-89
Research Scientist, SUNBOR, Osaka, Japan, 1989-92
Ruth Salta Junior Investigator Achievement Award, 1993
Faculty Scholars Award, Alzheimers Association, 1994-97
John S. Diekoff Award, Distinguished Graduate Teaching, 2001
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"Solution Structures of b-peptide and Its Constituent Fragments: Relation to Amyloid Deposition,? C. J. Barrow and M. G. Zagorski, Science 1991, 253, 179-182.
"Solution Conformations and Aggregational Properties of Synthetic Amyloid b-Peptides of Alzheimer's Disease. Analysis of Circular Dichroism Spectra,? C. J. Barrow, A. Yasuda, P. T. M. Kenny and M. G. Zagorski, J. Mol. Biol., 1992, 225, 1075-1093.
?Nicotine Inhibits Amyloid Formation by the b-Peptide,? A. R. Salomon, K. J. Marcinowski, R. P. Friedland, and M. G. Zagorski, Biochemistry, 1996, 35, 13568-13578.
?Trifluoroacetic Acid Pretreatment Reproducibly Disaggregates the Amyloid b-Peptide,? S.-C. Jao, K. Ma, J. Talafous, R. Orlando, and M. G. Zagorski, Amyloid, 1997, 4, 239-252.
?Solution Structures of Micelle-bound Amyloid b-(1-40) and b-(1-42) Peptides of Alzheimer?s Disease,? H. Shao, S.-C. Jao, K. Ma, and M. G. Zagorski, J. Mol. Biol., 1999, 285, 755-773.
?Methodological and Chemical Factors Affecting Amyloid b Peptide Amyloidogenicity,? M. G. Zagorski, J. Yang, H. Shao, K. Ma, H. Zeng, and A. Hong, in Amyloid and Other Protein Deposition, ed. R. Wetzel, Methods Enzymology, 1999, 309, 189-204.
?Solution Structure of the E200K Variant of Human Prion Protein,? Y. Zhang, W. Swietnicki, M. G. Zagorski, W. K. Surewicz, and F. D. Sönnichsen, J. Biol. Chem. 2000, 275, 33650-33654.
48. ?Melatonin Reverses the Profibrillogenic Activity of Apolipoprotein E4 on the Alzheimer Amyloid Ab Protein,? B. Poeggeler, L. Miravelle, M. G. Zagorski, T. Wisniewski, Y.-J. Chyan, Y. Zhang, H. Shao, T. Bryant-Thomas, R. Vidal, B. Frangione, J. Ghiso, and M. Pappolla, Biochemistry, 2001, 40, 14995-15001. |
more detailed structural and chemical data needs to be uncovered about the mechanisms associated with amyloid formation |
DeMattos el al PNAS 2002, 99, 10843-10848
Lashuel et al Nature 2002, 418, 291
Zou et al J. Neurosci. 2002, 22, 4833-4841 |
more clinical studies based on some chemical data, that is, skip toxicity and animal studies |
that the Abeta protein is a normal biological constituent that functions as an antioxidant and age-related changes in the brain prevents it funcioning as an antioxidant and accumulation of the reduced Abeta aggregates as plaques |
this will be a future grant |
teaching undergraduate organic chemistry to pre-meds |
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