|
|
|
| First Name: | Junichi | | Last Name: | Shioi | | Title: | Assistant Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | Mount Sinai School of Medicine | | Department: | Psychiatry | | Street Address 1: | Annenbwerg 22-72A | | Street Address 2: | One Gustave L. Levy Place | | City: | New York | | State/Province: | NY | | Zip/Postal Code: | 10029 | Country/Territory: | U.S.A. | | Phone: | (212)241-9378 | | Fax: | (212)241-0760 | | Email Address: |  |
Disclosure:
(view policy)
|
Member reports no financial or other potential conflicts of interest. [Last Modified: 14 September 2010]
|
|
|
View all comments by Junichi Shioi
|
Alzheimer Disease, Tauopathies
|
Animal Models, Molecular and Cell biology, Signal transduction, Neurobiology, Protein structure/chemistry, Apoptosis/Cell cycle, Oxidative Stress
|
Assistant Professor, Ph.D.
Department of Psychiatry
Mount Sinai School of Medicine
New York, NY |
Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK.
J Biol Chem. 2009 Jan 23;284(4):1954-61. Epub 2008 Nov 13
Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK.
J Neurosci. 2008 Jan 9;28(2):483-90.
Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK.
J Biol Chem. 2007 Jun 1;282(22):16155-63. Epub 2007 Apr 10.
Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK.
J Neurochem. 2007 May;101(3):674-81. Epub 2007 Jan 24.
Agiostratidou G, Muros RM, Shioi J, Marambaud P, Robakis NK.
J Neurochem. 2006 Feb;96(4):1182-8. Epub 2006 Jan 26.
Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK.
J Biol Chem. 2005 Oct 28;280(43):36007-12. Epub 2005 Aug 26.
Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK.
EMBO J. 2004 Jul 7;23(13):2586-96. Epub 2004 Jun 10.
Umehara Y, Yamada S, Nishimura S, Shioi J, Robakis NK, Sugahara K.
FEBS Lett. 2004 Jan 16;557(1-3):233-8.
Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM.
J Biol Chem. 2003 Dec 19;278(51):50970-7. Epub 2003 Sep 24.
Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK.
Cell. 2003 Sep 5;114(5):635-45.
|
A link between Abeta (or presenilin) and tau in AD
A link between progranulin and TDP-43 in FTLD |
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.
He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP, Greengard P.
Nature. 2010 Sep 2;467(7311):95-8.
A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Heilig EA, Xia W, Shen J, Kelleher RJ 3rd.
J Biol Chem. 2010 Jul 16;285(29):22350-9. Epub 2010 May 11.
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA.
Cell. 2010 Jun 25;141(7):1146-58. Epub 2010 Jun 10.
|
|
|
Home
