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| First Name: | Antonio | | Last Name: | Quiroz | | Title: | Dr | | Advanced Degrees: | MD, PhD | | Affiliation: | Professor | | Department: | Faculty of Chemistry | | Street Address 1: | Robalo 30 Col Justo Sierra | | Street Address 2: | Av 56 x Av Aviacion | | City: | Ciudad del Carmen | | State/Province: | Campeche | | Zip/Postal Code: | 21114 | Country/Territory: | Mexico | | Phone: | 930-1067909 | | Fax: | 938-11018 ext 2102 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 17 August 2005]
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View all comments by Antonio Quiroz
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Alzheimer Disease, Aging Process
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Oxidative Stress, biophysics, Molecular and Cell biology, Chemistry/Pharmacology, Clinical trials, Drug screening, Neuropathology
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I am an MD (so interested in theoretical physics that I studied this subject for 3 years). I was trained in oncology (11 years, including a course at the M.D. Anderson in Houston, 1962). I was invited as a postdoctoral researcher in biochemical genetics with Professor Susumu Ohno in California (1968-1970). Later, I finished my PhD degree in biophysics (Mexico IPN).I used to be a chemotherapy oncologist until 20 year ago, when I stopped my private practice and became dedicated to teaching and research.
I used to do research in bioinorganic aspects of copper or solid-state physics of copper (basically interested in cancer and AIDS).
I was developing a modified zeolita to be used for removing intestinal copper for a child with Menkes disease and surprisingly very small doses of our modified clinoptilolite improved my mother (94 years old) with Alzheimer disease. So I am just starting to prepare a protocol on Cu and Alzheimer disease. I never before was interested in AD. |
1. Quiroz-Gutierrez A., Kofman-Alfaro S. y Marquez-Monter H. (1967) "Chromosome markers in testicular seminoma". Lancet ii 306.
2. Quiroz-Gutiérrez A. y Ohno S. (1970) "The evidence of gene duplication for S-form NADP-linked isocitrate dehydrogenase in carp and gold fish". Biochem. Genet. 4: 95-99.
3. Quiroz-Gutiérrez A., Hernández P.T., Juárez G.C. & González I. (1992) Electrochemical studies on some Cu-Mo interactions: I. New trends in bio-inorganic molybdenum chemistry. Rev. Mex. Fís. 38, Sup 1: 152-159.
4. Juárez G.C., Hernández P.T., Quiroz-Gutiérrez A. & González I. (1992) Electrochemical studies on some Cu-Mo interactions: II. Synthesis and electrochemical behavior of the Histidyl-histidine-Cu complex. Rev. Mex. Fis. 38, Sup 1: 160-166.
5. Hernández P.T., Juárez G.C., Quiroz-Gutiérrez A. & González I. (1992) Electrochemical studies on some Cu-Mo interactions: III. The behavior of histidine-Cu complex alone and with tetrathiomolybdate (TTM) in dimethyl sulfoxide (DMSO), on glassy carbon electrode (GCE). Rev. Mex. Fis. 38, Sup 1: 167-173.
6. González I., Hernández P.T., Juárez G.C. & Quiroz-Gutiérrez A. (1992) Electrochemical studies on some Cu-Mo interactions: IV. Electrochemical interaction between histidine, Copper and tetrathiomolybdate at a hanging mercury drop electrode. Rev. Mex. Fis. 38, Sup 1: 174-181.
7. Santamaría, R., Quiroz-Gutiérrez, A. & Juárez-Gordiano, C. (1995) Structures and energetic properties of B-DNA nucleotides. Journal of Supramolecular Structure 357:161-170.
8. Quiroz-Gutiérrez A. (2000) Biophysical considerations and evolutionary aspects of DNA-dimer frequeny in AIDS retrovirus genomes. En: Heras, J.A. y Jiménez, R.V. Topics in Contemporary Physics. IPN. Pp 213-222. |
The study of which kind of copper complexes are present either in mouse models or Alzheimer tissues.Actually it is accepted (even ignored by MDs) that the different copper complexes behave in biological systems if the copper were more than three different chemical species (maybe using raman spectroscopy, near infrared spectroscopy, or nondestructive techniques, or by the different antagonists of each one of the copper centers). Maybe it is necessary to put together in the same discussion solid-state physics, bioinorganic chemistry and neurologists.Antonio Quiroz-Gutiérrez |
These two first are about clinoptilolite:
1. Zarkovic N, Zarkovic K, Kralj M, Borovic S, Sabolovic S, Blazi MP, Cipak A, Pavelic K.(2003) Anticancer and antioxidative effects of micronized zeolite clinoptilolite.Anticancer Res. 23(2B):1589-95.
2. Grce M, Pavelic K (2005) Antiviral properties of clinoptilolite. Microporous and Mesoporous Materials 79 (2005) 165–169This was the fist time of using clinoptilolite in humans (AIDS which is my mainly interest)
3. Ivkovic S, Deutsch U, Silberbach A, Walraph E, Mannel M. (2004) Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system. Adv Ther. 21(2):135-47. After I found clinoptilolite can improve AD patients, I found the Squiti paper:
4. Squitti R, Pasqualetti P, Dal Forno G, Moffa F, Cassetta E, Lupoi D, Vernieri F, Rossi L, Baldassini M, Rossini PM. (2005)Excess of serum copper not related to ceruloplasmin in Alzheimer disease. Neurology. 2005 Mar 22;64(6):1040-6. 5. Multhaup G, Schlicksupp A, Hesse L, et al. The amyloid precursorprotein of Alzheimer’s disease in the reduction of copper (II) to copper(I). Science 1996;271:1406–1409. |
Send me some of the mouse models of Alzheimer disease and we will develop a zeolite (clinoptilolite modifies for CuI or CuII) against Alzheimer disease with my own students. I do not need money or grants. Maybe I will send back to the United States the mouse treated. In order to study them,I will feel proud to initiate a protocol under my point of view. |
There was a double origin of life, and the roles that oxygen and copper were having in each of these are present in some of our pathologies. |
The relationship between copper and sodium in the first primordium of that origin of anaerobic life. |
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