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| First Name: | Riqiang | | Last Name: | Yan | | Title: | Associate Staff | | Advanced Degrees: | Ph.D. | | Affiliation: | Lerner Research Institute, Cleveland Clinic Foundation | | Department: | Neurosciences | | Street Address 1: | 9500 Euclid Avenue | | City: | Cleveland | | State/Province: | OH | | Zip/Postal Code: | 44195 | Country/Territory: | U.S.A. | | Phone: | 216-445-2690 | | Fax: | 216-444-7927 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 9 October 2003]
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View all comments by Riqiang Yan
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Polyglutamine Disorders (Huntington's, etc.), Stroke and Trauma, Tauopathies, Aging Process, Alzheimer Disease, Neuromuscular Disorders (ALS, etc.), Parkinson Disease
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A-beta PP/A-beta, Protein structure/chemistry, Animal Models
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Zong Z, Yan R, August A, Darnell JE Jr, Hanafusa, H. (1996) Unique signal transduction of Eyk: constitutive stimulation of the Jak-Stat pathway by an oncogenic receptor-like tyrosine kinase. EMBO. J. 15:4515-4525.
Yan R, Lou H., Darnell JE Jr, Dearolf CR. (1996) A Jak-Stat pathway regulates segmentation and wing vein formation. Proc. Natl. Acad. Sci. USA 93:5842-5847.
Yan R, Small S, Desplan C, Dearolf CR, Darnell JE Jr. (1996) Identification of a Stat gene that functions in Drosophila development. Cell 84:421-450.
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease J-secretase activity. Nature 402:533-537.
Yan R, Munzner JB, Shuck ME, Bienkowski MJ. (2001) BACE2 functions as an alternative a-secretase in cells. J Biol Chem. 276:34019-34027.
Yan R, Han P, Miao H, Greengard P, Xu, H. (2001) The transmembrane domain of the Alzheimer¡¯s b-secretase (BACE1) determines its late Golgi localization and access to APP substrate. J Biol Chem. 276:36788-36796.
Yang LB, Lindholm K, Yan R, Citron M, Konishi Y, Yang XL, Xia W, Beach T, Sue L, Wong P, Price D, Li R, Shen Y. (2003) Elevated b-Secretase Expression and Enzymatic Activity Detected in Sporadic Alzheimer¡¯s Brains. Nature Med. 9, 3-4.
Tomasselli AG, Qahwash I, Emmons TL, Lu Y, Leone JW, Lull JM, Fok KF, Bannow CA, Smith CW, Bienkowski MJ, Heinrikson RL, Yan R. (2003) Employing A Superior BACE1 Cleavage Sequence to Probe Cellular APP processing. J Neurochem.. 84, 1006-1017.
Jiang Z, Tang H, Havlioglu N, Zhang X, Stamm S, Yan R, Wu JY. (2003) Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J. Biol. Chem. 278, 18997-19007.
Qahwash I, Weiland KL, Lu Y, Saver EW, Kletzien RL, Yan R. (2003) Identification of A Mutant Amyloid Peptide That Predominantly Forms Neurotoxic Protofibrillar Aggregates. J. Biol. Chem. 278, 23187-23195.
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