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| First Name: | Vijendra | | Last Name: | Singh | | Title: | Neuroimmunologist | | Advanced Degrees: | PhD | | Street Address 1: | 914 Sudden Valley | | City: | Bellingham | | State/Province: | WA | | Zip/Postal Code: | 98229 | Country/Territory: | U.S.A. | | Phone: | 360-733-2279 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 30 October 2006]
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View all comments by Vijendra Singh
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Neurodevelopmental Disorders (Down syndrome, etc.), Aging Process, Alzheimer Disease
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A-beta PP/A-beta, Molecular and Cell biology, Proteomics, Neuroimmunology, Neuropathology, Neurobiology, Clinical trials, Oxidative Stress, Protein structure/chemistry, Stem cells
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Vijendra K. Singh, PhD, is an Associate Professor of Neuroimmunology in the Department of Biology and the Center for Integrated Biosystems at Utah State University in Logan, Utah. Originally from India, Dr. Singh received his doctorate from the University of British Columbia (UBC) in Vancouver, Canada, followed by a post-doctoral fellowship in neurochemistry and immunology. At UBC and British Columbia’s Children’s Hospital in Vancouver, he specialized in pediatric immunology, laboratory medicine, and neuroimmunology. Dr. Singh is an active member of the Society for Neuroscience (SfN), American Association for the Advancement of Science (AAAS), American Association of Immunologists (AAI), and American Society for Microbiology (ASM). He has served on the scientific advisory board of the Autism Autoimmunity Project in New Jersey and the M.I.N.D. Institute in California. He is a board member of the Center for Autistic Disorders (CASD) in Austin, Texas. He is also a member of the highly prestigious the International Who is Who of Intellectuals (UK) and the American Men and Women in Science (USA). In October 2002, Dr. Singh took home honors as one of 12 recipients of the O. Spurgeon English Humanitarian Award from the Psychiatric Association of Philadelphia and the National Foundation for Alternative Medicine (NFAM) in Washington, DC. Dr. Singh has devoted his entire career to academic research on neurodegenerative diseases and neurological disorders, including autism spectrum disorders (ASD), multiple sclerosis (MS), and Alzheimer’s disease (AD). |
1. Singh V.K., Immune-activation model in Alzheimer's disease. Molecular and Chemical Neuropathology 28 (1996) 105-111.
2. Singh, V.K., Cheng, J.F. and Leu, S.J., Effect of substance P and protein kinase inhibitors on -Amyloid peptide-induced proliferation of cultured brain cells. Brain Research 660: 353-356 (1994).
3. Singh, V.K., Neuroautoimmunity: Pathogenic Implications for Alzheimer's disease. Gerontology 43 (1997) 79-94.
4. Singh, V.K. and Guthikonda, P., Circulating cytokines in Alzheimer's disease. Journal of Psychiatric Research 31: 657-660 (1997).
5. Singh, V.K., Immunotherapy for brain diseases and mental illnesses. Progress in Drug Research 48: 129-146 (1997).
6. Singh, V.K., Autoimmunity and neurological disorders. Latitudes 4: 5-11 (1999).
7. Singh, V.K., Neuro-immunopathogenesis in Autism. In: New Frontier of Biology (edited by I. Berczi and R. M. Gorczynski), pp. 443-454 (2001), Elsevier Science B.V. Inc., The Netherlands.
8. Singh, V.K., Lin, S.X., Newell, E. and Courtney, N., Abnormal measles virus serology and CNS autoimmunity in children with autism. J. Biomedical Sciences 461: 359-364 (2002).
9. Singh, V.K., Cytokine Regulation in autism. In: Cytokines and Mental Health (edited by Ziad Kronfol (2003), pp. 369-383, Kluwer Academic Publishers, Boston, MA, USA.
10. Singh, V.K. and Rivas, W.H., Prevalence of serum antibodies to caudate nucleus in autistic children. Neuroscience Letters 355: 53-56 (2004).
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Too much emphasis on the "Amyloid beta-Protein Hypothesis" even though the amyloid deposition is an outcome and not the cause of the disease. Instead, novel hypothesis of viral etiology and autoimmune pathogenesis should be explored. |
1. Steinman L., Immune therapy for autoimmune diseases. Science 305: 212 (2004).
2. Salata OV., Applications of nanoparticles in biology and medicine. J. Nanobiotechnology 2: 1-6 (2004).
3. Bhatt DH et al., Cyclic AMP-induced repair of zebrafish spinal circuits. Science 305: 254 (2004). |
Role of Autoimmunity and Immunotherapy in Alzheimer's Disease (AD). The patients will benefit tremendously with immune modulation therapy (IMT), which needs to be investigated urgently. This excludes the AP-beta vaccine that will not likely be effective because this protein is not the cause of the disease. It's a bye product of AD and there is scientific evidence to that end. |
A virus-induced autoimmune response to brain contributes to Alzhemier's disease. Simply put, autoimmunity plays a major role in AD. |
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