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| First Name: | Othman | | Last Name: | Ghribi | | Title: | Associate Professor | | Advanced Degrees: | PhD | | Affiliation: | University of North Dakota | | Department: | Pharmacology, Physiology and Therapeutics | | Street Address 1: | 501 N. Columbia Road | | City: | Grand Forks | | State/Province: | ND | | Zip/Postal Code: | 58203 | Country/Territory: | U.S.A. | | Phone: | (701) 777 2522 | | Fax: | (701) 777-4490 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 3 November 2011]
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View all comments by Othman Ghribi
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Aging Process, Alzheimer Disease, Tauopathies, Neurodevelopmental Disorders (Down syndrome, etc.), Stroke and Trauma, Parkinson Disease, Neuromuscular Disorders (ALS, etc.)
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Neurobiology, Animal Models, Protein structure/chemistry, Proteomics, Tau/Cytoskeleton, Apoptosis/Cell cycle, Signal transduction, Neuropathology, Molecular and Cell biology, Oxidative Stress
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PhD in neuropharmacology, University Paris VI, France: regulation of extracellular concentration og EAA following transient forebrain ischemia.
Postdoc fellow: University of Quebec, Canada: Hypoxia in ApoE or APP transgenic mice
Research Associate: University of Virginia:
Apoptosis in aluminum-induced neurodegeneration
Research assistant professor, University of Virginia: mechanisms of neurotoxicity of Abeta perfused to rabbit brain. |
1: Prasanthi JR, Larson T, Schommer J, Ghribi O. Silencing GADD153/CHOP Gene
Expression Protects against Alzheimer's Disease-Like Pathology Induced by
27-Hydroxycholesterol in Rabbit Hippocampus. PLoS One. 2011;6(10):e26420. Epub
2011 Oct 14. PubMed PMID: 22046282.
2: Marwarha G, Dasari B, Ghribi O. Endoplasmic reticulum stress-induced CHOP
activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y
cells treated with the oxysterol 27-hydroxycholesterol. Cell Signal. 2011 Oct 1.
[Epub ahead of print] PubMed PMID: 21983012.
3: Dasari B, Prasanthi JR, Marwarha G, Singh BB, Ghribi O. Cholesterol-enriched
diet causes age-related macular degeneration-like pathology in rabbit retina. BMC
Ophthalmol. 2011 Aug 18;11:22. PubMed PMID: 21851605; PubMed Central PMCID:
PMC3170645.
4: Marwarha G, Prasanthi JR, Schommer J, Dasari B, Ghribi O. Molecular interplay
between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices
from rabbit hippocampus. Mol Neurodegener. 2011 Jun 8;6(1):41. PubMed PMID:
21651786; PubMed Central PMCID: PMC3121598.
5: Marwarha G, Dasari B, Prabhakara JP, Schommer J, Ghribi O. β-Amyloid regulates
leptin expression and tau phosphorylation through the mTORC1 signaling pathway. J
Neurochem. 2010 Oct;115(2):373-84. doi: 10.1111/j.1471-4159.2010.06929.x. Epub
2010 Aug 25. PubMed PMID: 20670375; PubMed Central PMCID: PMC2970652.
6: Prasanthi JR, Dasari B, Marwarha G, Larson T, Chen X, Geiger JD, Ghribi O.
Caffeine protects against oxidative stress and Alzheimer's disease-like pathology
in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med.
2010 Oct 15;49(7):1212-20. Epub 2010 Jul 16. PubMed PMID: 20638472; PubMed
Central PMCID: PMC2930139.
7: Marwarha G, Dasari B, Prasanthi JR, Schommer J, Ghribi O. Leptin reduces the
accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in
rabbit organotypic slices. J Alzheimers Dis. 2010;19(3):1007-19. PubMed PMID:
20157255; PubMed Central PMCID: PMC2924284.
8: Ghribi O. Potential mechanisms linking cholesterol to Alzheimer's disease-like
pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. J
Alzheimers Dis. 2008 Dec;15(4):673-84. Review. PubMed PMID: 19096164; PubMed
Central PMCID: PMC2805037.
9: Sharma S, Prasanthi R P J, Schommer E, Feist G, Ghribi O.
Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated
with alteration in IGF-1 signaling. Neurobiol Dis. 2008 Dec;32(3):426-32. Epub
2008 Aug 16. PubMed PMID: 18775495; PubMed Central PMCID: PMC2658815.
10: Ghribi O, Larsen B, Schrag M, Herman MM. High cholesterol content in neurons
increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit
hippocampus. Exp Neurol. 2006 Aug;200(2):460-7. Epub 2006 May 11. PubMed PMID:
16696972.
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Stress in the endoplasmic reticulum is an upstream event to Abeta and tau neurotoxic effects |
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