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| First Name: | Gael | | Last Name: | Barthet | | Title: | PhD | | Affiliation: | Mount Sinai School of Medicine, New York | | Department: | Psychiatry | | City: | New York | | State/Province: | NY | | Zip/Postal Code: | 10029 | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 16 September 2010]
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View all comments by Gael Barthet
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Aging Process, Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.)
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A-beta PP/A-beta, Animal Models, Apoptosis/Cell cycle, Chemistry/Pharmacology, Signal transduction, Neurotransmission, Protein structure/chemistry, Genetics, Molecular and Cell biology, Neurobiology, Proteomics, Drug screening, Bioinformatics/Statistics, Oxidative Stress, Brain imaging, Clinical trials
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Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A.
"Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling". EMBO J Vol. 28: 2706–18 (2009).
Kouchi Z, Barthet G*, Serban G, Georgakopoulos A, Shioi J, Robakis NK.
"p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide". J Biol Chem Vol. 284: 1954–61 (2009).
Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J. and Dumuis A.
"5-HT4 receptor activation of the ERK pathway depends on Src activation but not on G protein or β-arrestin signaling". Mol Biol Cell Vol. 18: 1979–1991 (2007).
Barthet G, Gaven F, Framery B, Shinjo K, Nakamura T, Claeysen S, Bockaert J, Dumuis A.
"Uncoupling and endocytosis of 5-HT4 receptors: Distinct molecular events with different GRK2 requirements". J Biol Chem 280: 27924-27934 (2005).
Ponimaskin E, Dumuis A, Gaven F, Barthet G, Heine M, Glebov K, Richter DW, Oppermann M.
"Palmitoylation of the 5-Hydroxytryptamine(4a) Receptor Regulates Receptor Phosphorylation, Desensitization and β-arrestin mediated Endocytosis". Mol Pharmacol 67: 1434-1443 (2005).
Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J.
"New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". J Cell Sci 117: 5367-5379 J (2004).
Marin P, Labasque M, Gavarini S, Barthet G, Dumuis A, Bockaert J and Becamel C
"5-HT receptor-interacting proteins: from fine-tuning of signaling to novel therapeutic targets in psychiatric diseases. Molecular aspects of G protein-coupled receptors : Interacting proteins and function". Nova Science Publishers
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Identification of the early causes. |
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