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| First Name: | Gianluigi | | Last Name: | Forloni | | Title: | PhD | | Affiliation: | Istituto di Ricerche Framacologiche "Mario Negri" | | Department: | Neuroscience | | Street Address 1: | Via G. La Masa 19 | | City: | Milano | | Zip/Postal Code: | 20156 | Country/Territory: | Italy | | Phone: | 39 0239014462 | | Fax: | 39 0239001619 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 21 February 2008]
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View all comments by Gianluigi Forloni
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Aging Process, Prion Diseases, Alzheimer Disease
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A-beta PP/A-beta, Apoptosis/Cell cycle, Proteomics, Genetics, Animal Models, Neurobiology, Drug screening
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Colombo A, Repici M, Pesaresi M, Santambrogio S, Forloni G, Borsello T. The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability.
Cell Death Differ. 2007 Oct;14(10):1845-8. Epub 2007 Jul 20.
PMID: 17641679
Fioriti L, Angeretti N, Colombo L, De Luigi A, Colombo A, Manzoni C, Morbin M, Tagliavini F, Salmona M, Chiesa R, Forloni G. Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann-Sträussler-Scheinker disease amyloid protein.
J Neurosci. 2007 Feb 14;27(7):1576-83.
PMID: 17301166
Forloni G, Terreni L, Bertani I, Fogliarino S, Invernizzi R, Assini A, Ribizzi G, Negro A, Calabrese E, Volonté MA, Mariani C, Franceschi M, Tabaton M, Bertoli A.
Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms.
Neurobiol Aging. 2002 Sep-Oct;23(5):957-76. Review.
PMID: 12392798
Forloni G, Iussich S, Awan T, Colombo L, Angeretti N, Girola L, Bertani I, Poli G, Caramelli M, Grazia Bruzzone M, Farina L, Limido L, Rossi G, Giaccone G, Ironside JW, Bugiani O, Salmona M, Tagliavini F.
Tetracyclines affect prion infectivity.
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10849-54.
PMID: 12149459
Forloni G, Colombo L, Girola L, Tagliavini F, Salmona M.
Anti-amyloidogenic activity of tetracyclines: studies in vitro.
FEBS Lett. 2001 Jan 5;487(3):404-7.
PMID: 11163366
Galbete JL, Martin TR, Peressini E, Modena P, Bianchi R, Forloni G. Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway.
Biochem J. 2000 Jun 1;348 Pt 2:307-13.
PMID: 10816423
Forloni G, Bertani I, Calella AM, Thaler F, Invernizzi R.
Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo.
Ann Neurol. 2000 May;47(5):632-40.
PMID: 10805334
Tagliavini F, McArthur RA, Canciani B, Giaccone G, Porro M, Bugiani M, Lievens PM, Bugiani O, Peri E, Dall'Ara P, Rocchi M, Poli G, Forloni G, Bandiera T, Varasi M, Suarato A, Cassutti P, Cervini MA, Lansen J, Salmona M, Post C.
Effectiveness of anthracycline against experimental prion disease in Syrian hamsters.
Science. 1997 May 16;276(5315):1119-22.
PMID: 9148807
Forloni G, Angeretti N, Chiesa R, Monzani E, Salmona M, Bugiani O, Tagliavini F.
Neurotoxicity of a prion protein fragment.
Nature. 1993 Apr 8;362(6420):543-6.
PMID: 8464494
Bendotti C, Forloni GL, Morgan RA, O'Hara BF, Oster-Granite ML, Reeves RH, Gearhart JD, Coyle JT.
Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice.
Proc Natl Acad Sci U S A. 1988 May;85(10):3628-32
PMID: 2897124 |
The relationship between beta amyloid deposition and neurofibrilalry tangles in AD and more in general the relationship between protein misfolding and neuronal degeneration |
Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT.
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Nature. 2008 Feb 7;451(7179):720-4.
PMID: 18256671
Sundelöf J, Giedraitis V, Irizarry MC, Sundström J, Ingelsson E, Rönnemaa E, Arnlöv J, Gunnarsson MD, Hyman BT, Basun H, Ingelsson M, Lannfelt L, Kilander L.
Plasma {beta} Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study.
Arch Neurol. 2008 Feb;65(2):256-63.
PMID: 18268197
Carroll JC, Pike CJ.
Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice.
Endocrinology. 2008 Feb 14; [Epub ahead of print]
PMID: 18276750 |
The longitudinal analysis of CSF by proteomic technique and numerous other parametrs in a large aged population with a follow up of several years to analyze the conversion in MCI and AD |
The combination of several causes induce the synaptic loss in AD, the dissection of the single contribution and the role of amyloid |
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