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| First Name: | Willem | | Last Name: | Annaert | | Title: | Prof. | | Advanced Degrees: | PhD | | Affiliation: | KULeuven&VIB | | Department: | Center for Human Genetics | | Street Address 1: | Lab. Membrane Trafficking, O&N1, Rm.9.696 | | Street Address 2: | Gasthuisberg, Herestraat 49 | | City: | Leuven | | Zip/Postal Code: | B-3000 | Country/Territory: | Belgium | | Phone: | +32-16330520 | | Fax: | +32-16330522 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 9 November 2006]
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Tauopathies, Alzheimer Disease
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Proteomics, A-beta PP/A-beta, Neurobiology, Protein structure/chemistry, Microscopy, Molecular and Cell biology
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Research institute, University
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• PhD research at Univ. Antwerp, Dept. Medicine, Belgium, 1987-93
• Postdoc Fellow, Yale University, HHMI, BCMM (BAEF/Collen-fellow/NIH), USA 10/94 - 05/96
• HHMI Postdoc Associate, Yale University, HHMI, BCMM, USA 05/96 - 09/96
• FWO-Postdoc Researcher, KULeuven, Center for Human Genetics, Belgium 10/96 - 09/99
• FWO-Senior Postdoc Researcher, KULeuven, Center for Human Genetics 10/99 - 09/02
• 10% Independent Researcher, KULeuven, Center for Human Genetics, Belgium as of 01/10/00
• Groupleader at VIB as of 01/10/01
• Professor, KULeuven, Center for Human Genetics, Belgium as of 01/10/02
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IKIN A.F., ANNAERT W.G., TAKEI K., DECAMILLI P., JAHN R., GREENGARD P. and BUXBAUM J.D. Amyloid precursor protein is localized in nerve terminals to Rab5-containing vesicular organelles distinct from the synaptic vesicle pathway. J. Biol. Chem., 271 (50), 31783-31786, 1996.
ANNAERT W.G., BECKER B., KISTNER U., RETH M. and JAHN R. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J. Cell Biol., 139(6), 1397-1410, 1997.
NNAERT W., and DE STROOPER B. Presenilins: molecular switches between proteolysis and signal transduction. Trends in Neurosc., 22(10), 439-443, 1999.
ANNAERT W.G., LEVESQUE L., CRAESSAERTS K., DIERINCK I., SNELLINGS G., WESTAWAY D., StGEORGE-HYSLOP P., FRASER P., and DE STROOPER B. Presenilin 1 controls -secretase processing of the amyloid precursor protein in pre-Golgi compartments of hippocampal neurons. J. Cell Biol., 147(2), 277-294, 1999.
DE STROOPER B., and ANNAERT W. Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Science, 113, 1857-1870, 2000.
CUPERS, P., BENTAHIR, M., CRAESSAERTS, K., ORLANS, I, VANDERSTICHELE, H., SAFTIG, P. DE STROOPER, B. and ANNAERT, W. The discrepancy between presenilin subcellular localization and -secretase processing of amyloid precursor protein.J. Cell Biol., 154(4), 731-740, 2001.
ANNAERT, W.G., ESSELENS, C., BOEVE, C., BAERT, V., SNELLINGS, G., CUPERS, P., CRAESSAERTS, K., DE STROOPER, B. Interaction with Telencephalin and the Amyloid Precursor Protein predicts a Ring structure for Presenilins. Neuron, 32, 579-589, 2001.
ANNAERT, W., and DE STROOPER, B. A Cell biological perspective on Alzheimer’s Disease. Annual Review of Cell Biology and Developmental Biology,18, 25-51, 2002.
ESSELENS, C., OORSCHOT, V., BAERT, V., RAEMAEKERS, T., SPITTAELS, K., SERNEELS, L., ZHENG, H., DE STROOPER, B., KLUMPERMAN, J., and ANNAERT, W. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J. Cell Biol. 166(7); 1041-54, 2004.
SPASIC, D., TOLIA, A., DILLEN, K., BAERT, V., DE STROOPER, B., VRIJENS, S. and ANNAERT, W. Presenilin 1 maintains a nine transmembrane topology throughout the secretory pathway. J. Biol. Chem., 281, 26569-77, 2006 (Jul 14; [Epub ahead of print]). |
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