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| First Name: | W. Taylor | | Last Name: | Kimberly | | Title: | Clinical Fellow in Neurology | | Advanced Degrees: | MD PhD | | Affiliation: | Massachusetts General Hospital | | Department: | Neurology | | Street Address 1: | 55 Fruit St | | City: | Boston | | State/Province: | MA | | Zip/Postal Code: | 02114 | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 28 March 2006]
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View all comments by W. Taylor Kimberly
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Neurodevelopmental Disorders (Down syndrome, etc.), Alzheimer Disease, Stroke and Trauma
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A-beta PP/A-beta, Signal transduction, Molecular and Cell biology
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University, Medical hospital
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Graduate thesis research with Dennis Selkoe. Focused on the identification of gamma-secretase and the normal biological function of APP and AICD. Postdoctoral work on APP function.
Currently in clinical training in Neurology at Brigham and Women's Hospital and Massachusetts General Hospital combined Neurology Partners program. |
1: Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ.
Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.
J Neurosci. 2005 Jun 8;25(23):5533-43.
PMID: 15944381
2: Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ.
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6382-7. Epub 2003 May 9.
PMID: 12740439
3: Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS.
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry. 2003 Jan 14;42(1):137-44.
PMID: 12515548
4: Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ.
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
J Biol Chem. 2002 Sep 20;277(38):35113-7. Epub 2002 Jul 18.
PMID: 12130643
5: Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS.
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. Epub 2002 Feb 26.
PMID: 11867728
6: Kimberly WT, Zheng JB, Guenette SY, Selkoe DJ.
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
J Biol Chem. 2001 Oct 26;276(43):40288-92. Epub 2001 Sep 5.
PMID: 11544248
7: Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS.
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Nat Cell Biol. 2000 Jul;2(7):428-34.
PMID: 10878808
8: Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ.
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
J Biol Chem. 2000 Feb 4;275(5):3173-8.
PMID: 10652302
9: Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Nature. 1999 Apr 8;398(6727):513-7.
PMID: 10206644
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Pharmacologic proof of the amyloid hypothesis in human trials. |
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