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| First Name: | Jurgen | | Last Name: | Claassen | | Title: | Dr | | Advanced Degrees: | MD, PhD | | Affiliation: | Radboud University Nijmegen Medical Center | | Department: | Geriatric Medicine | | Street Address 1: | 925 Geriatric Medicine | | Street Address 2: | PO Box 9101 | | City: | Nijmegen | | Zip/Postal Code: | 6500 HB | Country/Territory: | Netherlands | | Phone: | +31 24 3616772 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports the following financial or other potential conflicts of interest: [Last Modified: 2 July 2012]
I receive funding by Alzheimer Nederland and the Netherlands Heart Foundation
I have received speaker's remuneration from Jansen-Cilag (Johnson & Johnson)
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View all comments by Jurgen Claassen
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Alzheimer Disease, Aging Process
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Diagnosis, cerebral perfusion in AD and blood pressure regulation in AD, Brain imaging, Clinical trials, A-beta PP/A-beta
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Medical hospital, University, Research institute
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1: Oosterman JM, Oosterveld S, Rikkert MG, Claassen JA, Kessels RP. Medial
temporal lobe atrophy relates to executive dysfunction in Alzheimer's disease.
Int Psychogeriatr. 2012 Apr 25:1-9. [Epub ahead of print] PubMed PMID: 22717328.
2: Spies PE, Verbeek MM, van Groen T, Claassen JA. Reviewing reasons for the
decreased CSF Abeta42 concentration in Alzheimer. Front Biosci. 2012 Jun
1;17:2024-34. PubMed PMID: 22652762.
3: Slats D, Claassen JA, Verbeek MM, Overeem S. Reciprocal interactions between
sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin
and melatonin. Ageing Res Rev. 2012 Apr 30. [Epub ahead of print] PubMed PMID:
22575905.
4: Spies PE, Slats D, Rikkert MG, Tseng J, Claassen JA, Verbeek MM. CSF
α-synuclein concentrations do not fluctuate over hours and are not correlated to
amyloid β in humans. Neurosci Lett. 2011 Oct 31;504(3):336-8. Epub 2011 Oct 4.
PubMed PMID: 22001363.
5: Slats D, Claassen JA, Spies PE, Borm G, Besse KT, van Aalst W, Tseng J,
Sjögren MJ, Olde Rikkert MG, Verbeek MM. Hourly variability of cerebrospinal
fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers.
Neurobiol Aging. 2012 Apr;33(4):831.e1-9. Epub 2011 Aug 31. PubMed PMID:
21880396.
6: Aerts MB, Esselink RA, Claassen JA, Abdo WF, Bloem BR, Verbeek MM. CSF tau,
Aβ42, and MHPG differentiate dementia with lewy bodies from Alzheimer's disease.
J Alzheimers Dis. 2011;27(2):377-84. PubMed PMID: 21841257.
7: Claassen JA, Zhang R. Cerebral autoregulation in Alzheimer's disease. J Cereb
Blood Flow Metab. 2011 Jul;31(7):1572-7. doi: 10.1038/jcbfm.2011.69. Epub 2011
May 4. Review. PubMed PMID: 21540872; PubMed Central PMCID: PMC3137479.
8: van Beek AH, Lagro J, Olde-Rikkert MG, Zhang R, Claassen JA. Oscillations in
cerebral blood flow and cortical oxygenation in Alzheimer's disease. Neurobiol
Aging. 2012 Feb;33(2):428.e21-31. Epub 2011 Jan 5. PubMed PMID: 21208686.
9: van Beek AH, Sijbesma JC, Jansen RW, Rikkert MG, Claassen JA. Cortical oxygen
supply during postural hypotension is further decreased in Alzheimer's disease,
but unrelated to cholinesterase-inhibitor use. J Alzheimers Dis.
2010;21(2):519-26. PubMed PMID: 20555135.
10: Spies PE, Verbeek MM, Olde Rikkert MG, Claassen JA. Cerebrospinal fluid
biomarkers in Alzheimer's disease: are the hypotheses more dynamic than the
biomarkers? J Am Geriatr Soc. 2010 Aug;58(8):1619-20. doi:
10.1111/j.1532-5415.2010.03001.x. PubMed PMID: 20942893.
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Understanding the non-APP/PS1 mediated causes of the most common form of AD, "sporadic" AD, in the patient group with the highest prevalence of neurodegenrative disease: the elderly.
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AD is a disease of the neurovascular unit.
AD affects blood pressure regulation as well as cerebral autoregulation, causing disease progression through (repetitive) neuronal ischemia |
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