Antibody

Tau (Alz50)

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Clonality: monoclonal
Host: Mouse
Isotype: IgM
Methods: IC, IF, IH, IP, WB
Source: Available through Peter Davies.
Reactivity:
Recognizes a misfolded conformation of tau.

Immunogen/Epitope

Raised against human basal forebrain homogenate. Epitope subsequently determined to include amino acids 2-10 and 312-342 of tau.

Specificity

Recognizes a misfolded conformation of tau. 68 kDa Tau. Stains neuronal components of AD brain specimens but not normal brain specimens.

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Comments on this content

  1. This antibody recognizes a folded conformation of tau containing amino acids 2-10 and 312-342. We have used it successfully to detect misfolded tau in mouse models of tauopathy using array tomography, a relatively new imaging technique (Kopeikina et al., 2013).

    References:

    . Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2012 Oct 10; PubMed.

References

Other Citations

  1. Peter Davies

Further Reading

Papers

  1. . Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.
  2. . Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem. 2006 Feb 24;281(8):5037-41. PubMed.
  3. . Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901. PubMed.
  4. . Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001 Aug 24;293(5534):1487-91. PubMed.
  5. . Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science. 2001 Jul 27;293(5530):711-4. Epub 2001 Jun 14 PubMed.
  6. . Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J Neurosci Res. 1997 Apr 15;48(2):128-32. PubMed.