Prague: What Say You, Alois—Should It Be “Alzheimer-Fischer” Disease?
The 9th International AD/PD conference, held in Prague 11-15 March, made a big splash in the otherwise sleepy backwater of Alzheimer disease history...
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The 9th International AD/PD conference, held in Prague 11-15 March, made a big splash in the otherwise sleepy backwater of Alzheimer disease history...
Creutzfeldt-Jakob disease (CJD) is a fatal and transmissible neurodegenerative disease caused by a buildup of misfolded prion proteins in the brain...
What makes prions adopt toxic, self-perpetuating conformations?...
The road to reliable preclinical AD biomarkers has proven long and difficult...
When a patient steps into the doctor’s office and complains of memory problems, it would be nice if a few brain scans could reliably predict the person’s risk of future dementia...
The clamp, the boot, whatever you call it, if you find one on your car you’ll appreciate how a seemingly small attachment can keep its wheels from turning. In today’s Sciencexpress, researchers report that covalently clamping parkin with nitric oxide...
Could biopsy of olfactory epithelium yield early warnings of Alzheimer's disease (AD)? This possibility was raised by George Perry and colleagues who report that oxidative damage to olfactory neurons could be a harbinger of impending AD...
In tomorrow’s issue of Nature (pp. 784-788), Kun Ping Lu of Harvard Medical School and colleagues report that an enzyme, prolyl isomerase Pin1, binds to phosphorylated tau from Alzheimer’s patients...
Twin discordance—the manifestation of vastly different behaviors and susceptibilities to disease despite genetic identity—is a bit of a mystery...
In addition to immunotherapy, a meeting in Uppsala, Sweden, focused on recent progress in the development of novel disease biomarkers...
Alzheimer’s disease (AD) trials are extremely burdensome, sometimes unnecessarily so, and hard to comply with to the bitter end for most elderly people...
At the 33rd Annual Meeting of the Society for Neuroscience, Anthony Fink and M. Zhu of the University of California, Santa Cruz, reported that baicalein, a flavanoid used in traditional Chinese medicine, binds tightly to α-synuclein and even disaggregates...
Maas et al. (Abstract 2285) studied how phosphorylation of two different regions in tau proteins affects binding of tau protein to the plasma-membrane (PM). The two major phosphorylation sites studied...
It has previously been reported that the nerve growth factor (NGF) receptor trkA is depleted within the nucleus basalis, which is selectively damaged in early Alzheimer's disease...
The green light has been given for Mark Tuszynski and his colleagues from the University of California, San Diego, the Salk Institute, and UC Davis to start a Phase I (safety) trial of nerve growth factor (NGF) gene therapy for early onset Alzheimer's...
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