ADAPT Safety Data Released—Controversy Persists
Perhaps some good can come from the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT)...
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Perhaps some good can come from the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT)...
A recent population-based study supports the idea that in the oldest old, the relationship between plaques and tangles, and dementia, may be more legend than substance...
Back-to-back papers in today’s Science shed new light on the role that insulin and heat shock proteins may play in the aging process...
Neuronal progenitors are faced with many forks on the road to becoming one of more than 1,000 different neurons found in the human central nervous system...
Two new papers reveal how environmental influences can directly affect the activity of the APP-processing enzymes β-secretase (BACE1) and γ-secretase...
To fight against diseases of aging, scientists must understand the aging process itself...
Aβ peptides inhabit the human brain in various sizes and shapes, and an enduring question among Alzheimer’s disease researchers has been, Which of them is neurotoxic?...
Designed to speed transport and communication, bridges may also be useful for slowing disease. Researchers suggest as much in their review of one promising strategy for slowing the progression of ALS...
As part of the tangled web of pathology that leads to Alzheimer’s disease, inflammation is associated with local immune responses. For example, recent data indicate that both AD patients and elderly healthy people have...
Conventional wisdom says too much stress is a dangerous thing, weakening the heart, immune system, and perhaps the brain...
Researchers have been interested in the connections between stress and Alzheimer’s disease for years, but hard data remained elusive at first...
This week, two independent groups of academic researchers call for more transparency in the conduct of clinical trials...
The intramembrane protease activity of γ-secretase is a prime target for therapeutic strategies aimed at treating Alzheimer disease by...
A troika of papers provides evidence that γ-secretase is primarily localized intracellularly and needs the C-terminus of PEN-2 for complete integration...
Small interfereing RNAs are a hot new tool to manipulate gene expression. Read here about how to apply this method to primary neuronal cultures.
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