Mutated huntingtin may stow away in synaptic vesicles to sneak from one neuron to another.
Plenty of genetic risk factors for sporadic ALS are still waiting to be found, according to a new meta-analysis of GWAS data.
Scientists have turned a yeast heat shock protein into a powerful disaggregase that attacks TDP-43, FUS, and α-synuclein mutants.
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Repeat peptides made by the mutant C9ORF72 gene in ALS and FTD enter the nucleolus and obstruct RNA biogenesis.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
Researchers are ramping up efforts to target tau for Alzheimer’s and other tauopathies.
At AAIC 2014, crenezumab Phase 2 trial results stirred debate.
Could tweaking methodologies improve amyloid diagnosis and tracking?
A mouse study testing the combined effects of a BACE inhibitor and plaque-clearing antibody builds new support for a combination strategy aimed at reducing Aβ buildup in people.
A global effort to combat dementia has been conducting a yearlong series of events. Alzforum spoke with Dennis Gillings, who chairs the new World Dementia Council.
Researchers will have full access to a gargantuan genetic meta-analysis on the newly revamped PDGene database.
New data strengthens the evidence that dementia risk is dropping in developed countries, possibly due to better education and heart health.
In mouse models, Aβ aggregates injected into the belly invade the brain, as do prion seeds.