Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
In a large retrospective study, people with the highest plasma levels of an inflammatory protein experienced the greatest decline in reasoning abilities over the next 10 years.
In fruit flies that model ALS, presynaptic vesicles gather in unusually large clumps, amplifying signaling at the neuromuscular junction. Does this promote disease?
Novartis Pharmaceuticals Corporation will partner with the Banner Alzheimer's Institute testing experimental preclinical therapies in the upcoming Alzheimer's Prevention Initiative ApoE4 study. The study complements the API ADAD trial.