In mouse models, the Alzheimer’s risk gene TREM2 affects microglial behavior but does not lead to more amyloid deposition.
Scientists report that astrocytes help neurons destroy their unwanted mitochondria.
An antibody against ApoE helps clear plaques and improves cognition in AD model mice.
Conformations of misfolded tau survive injection from one mouse to the next, a property shared by prions.
Alpha-secretase does not necessarily pick up the slack when β-secretase cleavage of amyloid precursor protein wanes, a study in primates finds. It suggests APP can be processed in other ways.
Plenty of genetic risk factors for sporadic ALS are still waiting to be found, according to a new meta-analysis of GWAS data.
Scientists have turned a yeast heat shock protein into a powerful disaggregase that attacks TDP-43, FUS, and α-synuclein mutants.
Mutated huntingtin may stow away in synaptic vesicles to sneak from one neuron to another.
X-ray crystallography reveals secrets of the glutamate receptor.
While mice sleep, neurons sprout synapses to solidify fresh skills, according to a new study. The brain also keeps amyloid-β levels low while we snooze.
Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
Repeat peptides made by the mutant C9ORF72 gene in ALS and FTD enter the nucleolus and obstruct RNA biogenesis.