A Life of Cognitive Enrichment May Fend Off Dementia. But How?
Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
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Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
Some macrophages use their dying breath to emit a distress signal that could spell trouble for their neighbors.
Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
Heart-healthy foods containing omega-3 fatty acids, like salmon, slash risk of developing ALS by one-third.
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Repeat peptides made by the mutant C9ORF72 gene in ALS and FTD enter the nucleolus and obstruct RNA biogenesis.
Researchers are ramping up efforts to target tau for Alzheimer’s and other tauopathies.
MetLife rewards research on secretases, toxic Aβ transmission.
New twist to fluorescence-based microscopy lets scientists see up-close how Aβ aggregates in living cells.